Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
- Author:
- No author available
- Journal Title:
- Chinese Medical Journal
- Issue:
- 7
- DOI:
- 10.4103/0366-6999.178965
- Key Word:
- FCGR2A;FCGR3A;Single Nucleotide Polymorphisms;Takayasu Arteritis
Abstract： Background:Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology.The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population.Methods:Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332),the MLX region (rs665268),the FCGR2A/FCGR3A locus (rs 10919543),and the HLA-B/MICA locus (rs 12524487),associated with TA in different population,were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.A Chi-square test was used to test for genotype/allele frequencies variants.Results:Among the four SNPs,rs 10919543 was found to be significantly associated with TA in the studied population.The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] =6.532,95％ confidence interval [CI] =2.402-17.763,P ＜ 0.001) for TA.Among TA patients,the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs 10919543 (n =23,Eos =0.11 [0.08,0.17] × 109/L) than the GA + AA group (n =100,Eos =0.08 [0.05,0.13] × 109/L,P =0.028).No correlation between the genotypes of the other three SNPs and TA patients was observed.Conclusions:Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population.FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.
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