Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthma
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 11
- DOI:
- No doi available
- Key Word:
- asthma;airway inflammation;interleukin-17
Abstract： @@ Asthma is a chronic inflammatory airway disease characterized by the involvement of many cells (including eosinophils, mast cells, T cells, neutrophils and airway epithelial cells) and their cellular components.1 While airway eosinophilic inflammation is considered as a characteristic of asthma, our previous reports2,3 and other recent studies4,5 have demonstrated that neutrophils may play important roles in airway inflammation, or even in airway remodeling, particularly in severe asthma. The mechanisms underlying the neutrophil accumulation in asthmatic airway remain to be elucidated. Interleukin-8 (IL-8) is a potent chemotactic factor for neutrophils, and was demonstrated to be increased in asthmatic airways.6,7 More recent studies have shown that T-cell derived IL-17 can accumulate neutrophils via a IL-8 dependent pathway.8,9 Whether IL-17/IL-8 mechanism is involved in airway inflammation in severe asthma is not clear.
- [1]I D, Pavord,M M, Pizzichini,E, Pizzichini,etc.The use of induced sputum to investigate airway inflammation.[J].1997,52(6).
- [2]S E, Wenzel,S J, Szefler,D Y, Leung,etc.Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids.[J].1997,156.
- [3]Page N,Olivenstein R,Elias J,etc.IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.[J].2001,108(3).
- [4]JATAKANON ANON,UASUF CARINA,MAZIAK WAZIM,etc.Neutrophilic Inflammation in Severe Persistent Asthma[J].1999.
- [5]Hoshino H,Lotvall J,Gruenert DC,etc.Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.[J].1999,162(4).
- [6]Pierzchala W,Sozanska E,Barczyk A.Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.[J].2003,97(6).
- [7]Parker D,Pavord ID,Brightling CE,etc.Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids.[J].2002,57(10).
- [8]Cundall M,Sun Y,Miranda C,etc.Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids.[J].2003,112(6).