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Effects of hypoxia on promoter of telomerase reverse transcriptase and cell cycle distribution in neonatal rat cardiac myocytes
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- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 5
- DOI:
- No doi available
- Key Word:
- cardiac myocytes;hypoxia;cell cycle distribution;telomerase reverse transcriptase
Abstract： @@ On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how TERT is in keeping with CMs cycle distribution after birth and under hypoxia, and roughly understand how hypoxia affects activity of TERT promoter.
- [1]I, Horikawa,P L, Cable,C, Afshari,etc.Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.[J].1999,59.
- [2]Schneider MD,Oh H.The emerging role of telomerase in cardiac muscle cell growth and survival.[J].2002,34(7).
- [3]Castaldo C,Anversa P,Quaini F,etc.Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy.[J].2003,100(18).
- [4]Barlucchi L,Leri A,Deptala A,etc.Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart.[J].2001,98(15).
- [5]Nakano M.,Knowlton A. A.,Dibbs Z.,etc.Tumor Necrosis Factor-\u00a0 Confers Resistance to Hypoxic Injury in the Adult Mammalian Cardiac Myocyte[J].1998.
- [6]Leri A,Anversa P,Liew CC,etc.Telomerase activity in rat cardiac myocytes is age and gender dependent.[J].2000,32(3).