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Two subtelomeric chromosomal deletions in forty-six children with idiopathic mental retardation
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- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 9
- DOI:
- No doi available
- Key Word:
- in situ hybridization,fluorescence;chromosome deletion;mental retardation;developmental disabilities
Abstract： @@ Mental retardation (MR) affects approximately 3% of the population. In infancy and early childhood, mental retardation often presents as developmental delay. Unexplained MR is responsible for more than half of all cases.1,2 There is some evidence that subtle chromosomal rearrangements involved in subtelomeric regions (gene-rich regions), resulting in segmental aneuploidy and gene-dosage imbalance, are significant unrecognized causes of idiopathic mental retardation (IMR).3-10
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