Abstract: Objective To investigate the characteristics of multifocal electroretinograms (mf-ERG) of different phases in diabetic retinopathy (DR) and its clinical significance. Methods Multifocal electroretinograms in patients with DR (Ⅰ-Ⅱ stage) were tested with VERIS Ⅳ system. Results In Ⅰ-Ⅱ stage, the absolute values of N1, P1 and N2 response densities, and the N1-P1 and P1-N2 response densities were attenuated is a field of about 45 degrees in diameter. Conclusion As a new objective and quantitative examination for spatial visual function, multifocal electroretinograms may be valuable in the diagnosis of diabetic retinopathy.