Abstract： Vaginal drug delivery has attracted great attention due to its advantages such as rich blood supply,large surface area of vagina and avoidance of the hepatic first-pass effect.However,there are still issues such as leakage and discomfort in application of traditional drug dosage forms for vaginal administration.At present,strategies such as bioadhesive materials,thermosensitive materials,pH responsive materials,mucosal penetration techniques and nano technologies have been proposed to improve the retention time,permeability,and release characteristics of drugs in the vagina.Based on the physiological structure and characteristics of the vagina,this review summarizes the delivery strategies and techniques of drug delivery through the vaginal mucosa,hoping to provide a reference for the development of vaginal topical medication and uterine-targeting delivery products.