Abstract： Dynamic vapor sorption(DVS)technology is served as a crucial tool for the examination of pharmaceutical crystal forms and co-crystals.Not only can DVS technology assess moisture sorption performance of an API,but it also probes into phase transition issues,co-crystal screening,quantification of amorphous content at low levels in crystalline materials,as well as the miscellaneous.At present,many countries and regions have included DVS technology into their pharmacopoeias for the exploration of water-solid interactions.However,the Chinese pharmacopoeia has not recorded this technology.This paper provides an overview of the application and advance of DVS technology in the investigation of pharmaceutical crystal forms and co-crystals,as a reference for related research on polymorphism of drugs.