Abstract： Objective:To explore the severity,addiction and harm of etomidate-containing e-cigarette abuse,and to provide a real scientific basis for the relevant departments to control the drug.Methods:A self-designed questionnaire on etomidate abusers was conducted to collect and organize relevant data from 560 hospitalized patients who used tobacco and e-cigarette containing etomidate from March to July 2023.Results:The cases in this group were mainly male and unmarried,and the educational level was low.There were 88 cases of minors,of which 34 cases were more female than male.Most of them appeared in June and July.The main form of abuse was e-cigarettes.The main reasons for abuse were temptation and insufficient understanding of the harm of etomidate,followed by friend pressure and curiosity.The history of abuse was mostly within 1 month and the longest was 3 years.There were 103 patients with dependence syndrome,including 57 cases of impulsive aggression.There were 150 cases of falls caused by the abuse of etomidate e-cigarettes,as well as fractures,car accidents,injuries,and self-mutilation.In addition,most patients are accompanied by physical diseases,such as hypokalemia,menstrual disorders,darkened skin,weight loss;after comprehensive treatment,the short-term effect was ideal,and the cure rate was 91.57%.Conclusion:The abuse of etomidate e-cigarettes is very serious,with strong addiction,which seriously endangers human life safety.It is suggested that relevant departments should take charge as soon as possible to reduce further harm to human beings.Discover abuse patients,as soon as possible to the formal detoxification medical institutions system treatment.