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The effect of 1, 25?dihydroxyvitamin D3 on peripheral nerve function in diabetic mice
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006‑6187.2022.08.012
- Key Word:
- 糖尿病小鼠;糖尿病周围神经病变;1,25-二羟基维生素D3;神经功能
Abstract： 目的 探讨1,25?二羟基维生素D3[1,25(OH)2D3]对DM小鼠周围神经功能的影响.方法 C57BL/6J小鼠腹腔注射STZ构建DM小鼠模型,随机分为DM组(DM)、DM第1周1,25(OH)2D3治疗组(1w?DM)、DM第2周1,25(OH)2D3治疗组(2w?DM)、DM周围神经病变1,25(OH)2D3治疗组(DPN)以及DM第1周溶剂对照组(1w?DMC)、DM第2周溶剂对照组(2w?DMC)、DPN溶剂对照组(DPNC),每组各15只,并设置正常对照组(NC)10只.建模后第1、2、4周分别对1w?DM、2w?DM、DPN组予1,25(OH)2D3腹腔注射,连续5 d;监测各组血糖、体重、触觉、热痛觉及协调能力,8周后收集血清检测25(OH)D3水平.结果 与DM组比较,1w?DM、2w?DM组第8周体重升高(P<0.05),血糖降低(P<0.05),协调运动时间、血清25(OH)D3水平升高(P<0.05或P<0.01),触觉反应时间、热痛觉反应时间更短(P<0.05).结论 在DM神经功能受损前,1,25(OH)2D3治疗可有改善DM小鼠周围神经功能.
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