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Application of continuous glucose monitoring in metabolic associated fatty liver disease
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006‑6187.2022.08.001
- Key Word:
- 糖尿病,2型;代谢相关脂肪性肝病;持续血糖监测;血糖目标范围内时间;高于目标范围时间百分比
Abstract： 目的 探讨持续血糖监测(CGM)在T2DM合并代谢相关脂肪性肝病(MAFLD)患者中的应用.方法 选取2017年10月至2020年10月于苏州大学附属第一医院内分泌科住院的T2DM患者148例,分为单纯T2DM组(T2DM,n=87)及T2DM合并MAFLD组(T2DM+MAFLD,n=61),比较两组一般资料及CGM相关指标.结果 T2DM+MAFLD组BMI、谷丙转氨酶、谷草转氨酶、谷氨酰转肽酶、TG、二甲双胍用药比例及血糖高于目标范围时间(TAR)高于T2DM组(P<0.05),HDL?C及血糖目标范围内时间(TIR)低于T2DM组(P<0.05).Pearson相关分析显示,MAFLD患者TIR与2 hC?P呈正相关(P<0.05),与DM病程、HbA1c、平均血糖波动幅度、血糖水平标准差、TAR呈负相关(P<0.05).多元线性回归分析显示,TAR是MAFLD患者TIR的影响因素.结论 MAFLD患者TIR降低,TAR升高,TAR是TIR的影响因素.
- [1]Thomas W Martens,Richard M Bergenstal,Teresa Pearson,etc.Making sense of glucose metrics in diabetes: linkage between postprandial glucose (PPG), time in range (TIR) & hemoglobin A1c (A1C)[J].2021,133(3).
- [2]Lu, Jingyi,Ma, Xiaojing,Zhou, Jian,etc.Association of Time in Range, as Assessed by Continuous Glucose Monitoring, With Diabetic Retinopathy in Type 2 Diabetes[J].2018,41(11).
- [3]Yin, Xueyao,Zheng, Fenping,Pan, Qianqian,etc.Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening[J].2015,55(3).
- [4]Jee Hee,Yoo,Jae Hyeon,Kim.Time in Range from Continuous Glucose Monitoring: A Novel Metric for Glycemic Control.[J].2020,44(6).
- [5]Babaya Naru,Noso Shinsuke,Hiromine Yoshihisa,etc.Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes[J].2021,11(1).
- [6]Tilg, Herbert,Moschen, Alexander R.,Roden, Michael.NAFLD and diabetes mellitus[J].2017,14(1).
- [7].Estimation of Hemoglobin A1c from Continuous Glucose Monitoring Data in Individuals with Type 1 Diabetes: Is Time In Range All We Need?[J].2020,22(7).
- [8]Lomonaco, Romina,Bril, Fernando,Portillo-Sanchez, Paola,etc.Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes[J].2016,39(4).
- [9]Beck, Roy W.,Bergenstal, Richard M.,Riddlesworth, Tonya D.,etc.Validation of Time in Range as an Outcome Measure for Diabetes Clinical Trials[J].2019,42(3).
- [10]Alexander, Charles M.,Amiel, Stephanie,Beck, Roy,etc.Need for Regulatory Change to Incorporate Beyond A1C Glycemic Metrics[J].2018,41(6).
- [11]Danne, Thomas,Nimri, Revital,Battelino, Tadej,etc.International Consensus on Use of Continuous Glucose Monitoring[J].2017,40(12).
- [12]Jingyi Lu,Xiaojing Ma,Yun Shen,etc.Time in Range Is Associated with Carotid Intima-Media Thickness in Type 2 Diabetes[J].2020,22(2).
- [13]Fumi, Honda,Akira, Hiramatsu,Hideyuki, Hyogo,etc.Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring.[J].2018,13(4).