Abstract： Objective To explore the effect of Liraglutide on islet function and islet microvascular endothelial cells in mice with pre-diabetes . Methods Thirty male C57BL/6J mice were randomly divided into three groups :control group (Con ,n= 10) ,high-fat dietgroup (HF ,n= 10) and high-fat diet plus Liraglutide group (LH ,n= 10) .The FBG ,FIns ,the expression of insulin ,CD31 ,VEGF-A ,mRNA of iNOS and IL-1βin islet were detected . Results There was no significant difference in FBG among the three groups (P>0.05) .The concentration of insulin in the islets was higher [(0.217 ± 0.002)vs(0.195 ± 0.002)ng/ml ,P<0.05] ,the levels of CD31[(0.196 ± 0.002)vs (0.245 ± 0.004)] ,VEGF-A[(0.265 ± 0.003) vs (0.413 ± 0.005)] ,IL-1β[(1.13 ± 0.03) vs (1.54 ± 0.02)] ,and iNOS[(1.28 ± 0.02) vs (1.65 ± 0.03)] were lower in LH group than in HF group . Conclusion Liraglutide can improve pancreatic islet function and protect islet microvascular endothelial cells in mice with pre-diabetes .