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Progress of umbilical cord mesenchymal stem cell transplantation for the treatment of diabetic foot
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 10
- DOI:
- 10.3969/j.issn.1006-6187.2017.04.021
- Key Word:
- 脐带间充质干细胞;糖尿病足;Wnt/β-catenin信号通路;MicroRNA-21;Umbilical cord mesenchymal stem cells;Diabetes foot;Wnt/β-catenin signaling pathway;MicroRNA-21
Abstract： Patients with diabetes have about 15％ lifetime risk of developing a foot ulcer worldwide,and 6 ％ of which need hospitalized treatment.So far,treatment of diabetic foot (DF) remains one of the burning issues for health care in diabetic populations and the DF treatment still deemed dismal and unsatisfactory,more effective treatment strategies are warranted.Umbilical cord mesenchymal stem cells(UCMSCs) are progenitor cells which,have the ability of self-renewal and multilineage differentiation.It can promote the foot wound healing through the improvement of diabetic lower limb ischemia,repair diabetes peripheral neuropathy and immune regulation.The Wnt/β-catenin signaling pathway plays an important regulatory role in UCMSC transplantation treatment.The UCMSC transplantation has become a novel cell therapeutic protocol for the treatment of diabetes mellitus and its complications.It has a broad application prospect.
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