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Effect of Cinnamic Aldehyde on the antioxidant activity in pancreas of db/db mice
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2016.08.017
- Key Word:
- 肉桂醛;胰腺细胞;抗氧化;线粒体;Cinnamic aldehyde(CA);Pancreatic cells;Antioxidant;Mitochondria
Abstract： 目的 观察肉桂醛(CA)对db/db小鼠胰腺细胞的抗氧化活性的影响,并探讨其降糖机制.方法 将21只db/db小鼠随机分为对照组(Con)、CA低剂量组、CA高剂量组,分别予安慰剂,CA低剂量和CA高剂量.灌胃3周后,检测各组血糖、血清和胰腺组织抗氧化酶活性及胰腺细胞线粒体活性等.结果 与Con组比较,CA低剂量和CA高剂量组血糖降低(P＜0.05);CA高剂量组胰腺抗氧化酶的活性均增强,胰腺细胞线粒体活性氧簇(ROS)量降低(P＜0.05);CA低剂量组ROS量与Con组比较,差异无统计学意义(P＞0.05).此外,给药组线粒体膜电位均高于Con组,CA高剂量组琥珀酸脱氢酶(SDH)活性增加(P＜0.05). 结论 CA能降低db/db小鼠血糖,其作用机制是通过提高胰腺组织抗氧化酶活性,减少体ROS等自由基的产生,从而保护线粒体功能,保护胰腺细胞.
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