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Association between serum uric acid and nonalcoholic fatty liver disease
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2016.08.002
- Key Word:
- 血清尿酸;非酒精性脂肪性肝病;Serum uric acid;Nonalcoholic fatty liver disease(NAFLD)
Abstract： 目的 研究普通人群血清尿酸(SUA)水平与非酒精性脂肪性肝病(NAFLD)的关系.方法 收集27615名体检者的临床和生化资料,并通过腹部B超诊断NAFLD.将研究对象分为非NAFLD(Non-NAFLD)组和NAFLD组,再根据不同性别的SUA四分位数将研究对象分为4组(Q1～Q4),比较各组临床和生化特征. 结果 本研究中,NAFLD及高尿酸血症(HUA)的患病率分别为27.1％和19.6％.随SUA水平的升高,BMI、SBP、DBP、TG、TC、LDL-C、Scr、ALT和AST均升高,HDL-C降低(趋势P＜0.001);从Q1组至Q4组,NAFLD的患病率逐渐递增(13.5％ vs 19.9％ vs 29.3％ vs 46.2％,趋势P＜0.001);多元Logistic回归分析发现,校正性别、年龄、BMI、BP、血脂等因素后,Q2～Q4组的NAFLD患病风险较Q1组分别增加24％、62％和137％ (P＜0.001). 结论 在普通人群中,SUA与NAFLD密切相关,可能是NAFLD发生的独立危险因素.
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