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The correlation between thyroid function and fibrinogen in patients with T2DM
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2014.06.008
- Key Word:
- 糖尿病,2型;甲状腺;纤维蛋白原;Diabetes mellitus,type 2;Thyroid;Fibrinogen(FIB)
Abstract： 目的 探讨T2DM患者甲状腺功能与纤维蛋白原(FIB)的相关性. 方法 选取T2DM患者502例,测定FIB、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)和临床生化指标,采用方差分析、Spearman相关分析及多元逐步回归分析甲状腺功能与FIB的相关性. 结果 (1)FT3与FIB呈负相关(r=-0.331,P＜0.01).(2)甲减组FIB高于甲亢组[(3.765±1.089)vs(3.346±0.879)pmol/L,P＜0.01],与正常组[(3.232±0.985) pmol/L]比较差异无统计学意义;按FIB由低到高四分位间距分组,FT3依次为(4.54±0.96),(4.47±0.81),(3.94±1.13)及(3.67±0.95)pmol/L,P0～组与P25～组均高于P75～组(P＜0.01).(3)年龄、[脂蛋白LP-(a)]、C-RP、HbA1c是FIB的独立影响因素(β=0.382,0.272,0.552,0.221;P＜0.05或P＜0.01);FT3与FIB呈负相关(β=--0.289,P＜0.01),且与C-RP呈依赖性. 结论 T2DM患者年龄、LP-(a)、C-RP、HbA1 c及FT3均与FIB相关,甲状腺激素可能通过炎症机制影响FIB.
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