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The change of the urinary 8-Hydroxy-2'-deoxyguanine in patients with IGT and type 2 diabetes and its clinical significance
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2014.06.004
- Key Word:
- 8-羟基脱氧鸟苷;糖尿病,2型;糖耐减低;氧化应激;8-hydroxy-2'-deoxyguanosine (8-OHdG);Diabetes mellitus,type 2;Impaired glucose tolerance(IGT);Oxidative stress (OS)
Abstract： 目的 探讨IGT及T2DM患者尿8-羟基脱氧鸟苷(8-OHdG)的水平. 方法 选取IGT者(IGT组)、T2DM患者(T2DM组)及正常对照(NC)者各40名.收集24 h尿,通过ELISA检测尿液中8-OHdG含量,苦味酸法测定尿肌酐(Ucr)浓度,采用酶法测定血糖、肾功能,高效液相色谱法测定HbA1 c,Clauss法测定纤维蛋白原(FIB). 结果 8-OHdG在NC、IGT、T2DM组逐次递增[(6.97±2.13)vs(9.32±2.51)vs(12.26±3.57) ng/mgCr],比较差异有统计学意义(P＜0.05).经相关性分析及多元逐步回归分析发现,2 hPG与尿8-OHdG呈正相关,对尿8-OHdG水平影响较大. 结论 (1)IGT和T2DM患者尿8-OHdG水平升高;(2)2 hPG是影响体内氧化应激的主要因素.
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