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Clinical significance of detection of serum MCP-1, TNF-α, hsC-RP, PAI-1, LPS and AGI for diagnosis of early type 2 diabetic nephropathy
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2012.02.006
- Key Word:
- 糖尿病性肾脏疾病;炎症标志物
Abstract： 目的 探讨血清单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子α(TNF-α)、高敏C反应蛋白(hsC-RP)、血浆纤溶酶原激活物抑制物1(PAI-1)、脂多糖(LPS)及晚期糖基化指数(AGI)水平与T2DM早期肾病的关系. 方法 78例糖尿病患者根据即时尿标本的白蛋白/肌酐(UAlb/Cr)水平分为:正常白蛋白尿(NUAlb)组(n=40)、微量白蛋白尿(MUAlb)组(n=38).观察各组患者MCP-1、TNF-α、hsC-RP、PAI-1、LPS、AGI水平的变化,并与健康对照(NC)组(n=40)进行比较. 结果 NUAlb、MUAlb组的MCP-1、TNF-α、hsC-RP、PAI-1、LPS及AGI水平均明显高于NC组(P＜0.01)；MUAlb组的上述炎症标志物水平明显高于NUAlb组(P＜0.05).将性别、年龄、BMI、基线HbA1c、是否合并高血压、血脂紊乱作为协变量控制后,UAlb/Cr与MCP-1、LPS、TNF-α、PAI-1、hsC-RP、AGI作偏相关分析,结果呈显著正相关(r=0.69,0.61,0.64,0.76,0.67,0.62,P均＜0.01). 结论 早期检测血清MCP-1、TNF-α、hsCRP、PAI-1、LPS及AGI水平的变化,对于糖尿病性肾脏疾病的早期诊断和及时治疗有重要意义.
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