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脂肪因子apelin与代谢综合征
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 7
- DOI:
- 10.3321/j.issn:1006-6187.2008.07.021
- Key Word:
- Apelin代谢综合征;肥胖;高血压;糖尿病
Abstract： @@ Apelin是1998年由Tatemoto等[1]首次通过反向药理学方法从牛胃的分泌物中提取并纯化的孤儿G蛋白偶联受体一血管紧张素Ⅱ(ATⅡ)1型受体相关蛋白(APJ)的天然配体,一种新发现的具有重要生物学作用的心血管活性多肽,与AT Ⅱ具有31%同源性,属于肾素一血管紧张素系统(RAS)新的组分,具有正性肌力、扩张血管、降低血压、减少抗利尿激素释放、调节摄水及垂体激素释放、调整生物节律和抑制人类免疫缺陷病毒侵入等多种生物学效应(图1).
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