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线粒体tRNATEU(UUR)基因点突变与1型糖尿病关系的研究
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 2
- DOI:
- 10.3321/j.issn:1006-6187.2001.02.020
- Key Word:
- No keyword available
Abstract： @@近年来发现线粒体tRNALEU(UUR)基因点突变是糖尿病的致病突变之一［1，2］，我们对线粒体tRNALEU(UUR)基因3243位点A→G突变与1 型糖尿病的关系进行了研究，旨在揭示该基因点突变在我国东北地区汉族1型糖尿病患者中的情况以及与自身免疫导致的1型糖尿病有无关联。 材料与方法 1.实验对象：选取57例1型糖尿病患者，祖籍三代均为东北地区汉族居民，其中以酮症起病者23例，男性12例，女性11例，平均年龄14.9±1.6岁，发病年龄10.0±1.5岁，体重指数17 .8 4±1.55kg/m2；缓慢进展型1型糖尿病34例，男性21例，女性13例，平均年龄45.2±2.0岁，发病年龄40.7±2.5岁，体重指数22.25±1.64kg/m2。
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