Abstract： Objective:To evaluate the accuracy and safety of 3D printed orbital model assisted preforming titanium mesh in repairing orbital wall fracture.Methods:Thirty-six patients with orbital fracture were divided into two groups:18 patients in group A were in the experimental group. 3D printed orbital model was used to assist the pre-formed titanium mesh to repair orbital wall fracture. Eighteen patients in group B were used as the control group to repair orbital wall fracture with traditional 3D preformed titanium mesh. Postoperative observation was made of the improvement of orbital CT, enophthalmia and diplopia in the two groups, and the therapeutic effect of 3D printed orbital model assisted with preformed titanium mesh in repairing orbital wall fracture was evaluated.Results:In the experimental group, the edge of titanium mesh was exactly consistent with the fracture edge on postoperative orbital CT. Correction rate of enophthalmia:there were statistically significant differences between group A 2 weeks after surgery and 3 and 6 months after surgery( P <0.05), and there were no statistically significant differences between group A 3 months after surgery and 6 months after surgery( P >0.05). There was no statistically significant difference in each postoperative stage in group B( P >0.05). Corrections of diplopia:There was no significant difference between group A and group B 2 weeks after operation, 3 months and 6 months after operation(P > 0.05). Conclusions:Using 3D printed orbital model to assist preformed titanium mesh can repair the orbit more accurately and safely, and improve the cure rate of enophthalmos and diplopia.