Abstract： Objective:To investigate the influence of double incision vs single incision phacoemusification aspiration(PEA) on cornea of patients with Age-related cataract (ARC) .Methods:Clinical data of 256 cases(272 eyes) of patients with Age-related cataract(ARC) by PEA combined with intraocular lens implantation were analyzed, retrospectively, including control group(150 eyes of 137 cases)with double incision PEA and observation group(122 eyes of 119 cases )with single incision PEA. The surgical time, cumulative dissipated energy(CDE), ultrasound time, perfusion volume, vision, surgically induced astigmatism(SIA), 10mm-cornea volume(10mm-CV), central corneal thickness(CCT) and corneal endothelial cell parameters of 2 groups were compared.Results:The difference in the surgical time, CDE, ultrasound time and perfusion volume between 2 groups were not significant( P >0.05). The levels of naked eye vision and corrected distant vision of 1 week after operation in observation group were significantly higher than that in. control group ( P <0.05). The levels of cornea anterior surface SIA of 1 week after operation in observation group was significantly lower than that in control group( P <0.05). The levels of 10mm-CV and CCT of 1 week after operation in observation group were significantly lower than that in control group( P <0.05). The levels of endothelial cells loss of 1 week, 4 weeks and 12 weeks after operation in observation group were significantly lower than that in control group ( P <0.05). The levels of corneal endothelial cell average size in 1 week after operation in observation group were significantly lower than that in control group ( P <0.05). Conclusions:Compared with double-incision PEA, single-incision PEA combined with intraocular lens implantation in the treatment of patients with ARC can effectively relieve corneal injury, accelerate the recovery process after operaiton and be helpful to improve visual quality.