Paper - WANFANG MED ONLINE

You Position: Home > Paper

MicroRNAs as biomarkers of diabetic retinopathy and disease progression

( views:35, downloads:1 )

Author:: No author available

Journal Title:: Neural Regeneration Research

Issue:: 11

DOI:: 10.4103/1673-5374.259602

Key Word:: diabetes;retinopathy;diagnosis;disease progression;microRNAs;biomarkers;blood serum/plasma;vitreous humor;humans

Abstract： Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its compli-cations include cardiovascular disease (e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye complications (e.g., glaucoma, cataracts, retinopathy, and macular edema). In patients with either type 1 or type 2 diabetes mellitus, diabetic retinopathy is the leading cause of visual impairment or blindness. It is characterized by progressive changes in the retinal microvasculature. The progression from nonproliferative diabetic retinopathy to a more advanced stage of moderate to severe nonproliferative diabetic retinop-athy and proliferative diabetic retinopathy occurs very quickly after diagnosis of mild nonproliferative diabetic retinopathy. The etiology of diabetic retinopathy is unclear, and present treatments have limited effectiveness. Currently diabetic retinopathy can only be diagnosed by a trained specialist, which reduces the population that can be examined. A screening biomarker of diabetic retinopathy with high sensitivity and specificity would aid considerably in identifying those individuals in need of clinical assessment and treatment. The majority of the studies reviewed identified specific microRNAs in blood serum/plasma able to distinguish diabetic patients with retinopathy from those without retinopathy and for the progresion of the disease from nonproliferative diabetic retinopathy to proliferative diabetic retinopathy. In addition, certain microRNAs in vitreous humor were dysregulated in proliferative diabetic retinopathy compared to controls. A very high percentage of patients with diabetic retinopathy develop Alzheimer’s disease. Thus, identifying diabetic retinopathy by measurement of suitable biomarkers would also enable better screening and treatment of those individuals at risk of Alzheimer’s disease.

Reference

[1]Willeit,P.,Drozdov,I.,Mayr,M.,etc.Profiling of circulating microRNAs: From single biomarkers to re-wired networks[J].2012,93(4).
[2]Jianping, Ma,Jufang, Wang,Yanfen, Liu,etc.Comparisons of serum miRNA expression profiles in patients with diabetic retinopathy and type 2 diabetes mellitus.[J].2017,72(2).
[3]Sivaprasad S,Mathew R,Salam A.Treatment of proliferative diabetic retinopathy with anti-VEGF agents.[J].2011,89(5).
[4]Murray,A.R.,Chen,Q.,Takahashi,Y.,etc.MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model[J].2013,54(3).
[5]Keino, Hiroshi,Hirakata, Akito,Hirota, Kazunari,etc.Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy[J].2015,253(3).
[6]Ayumi, Usui-Ouchi,Yasuo, Ouchi,Masatoshi, Kiyokawa,etc.Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease.[J].2016.
[7]N, Gupta,S, Mansoor,A, Sharma,etc.Diabetic retinopathy and VEGF.[J].2013,7.
[8]Willeit J,Willeit P,Kiechl S,etc.Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes.[J].2010,107(6).
[9]He-Nan,Liu,Nan-Jue,Cao,Xun,Li,etc.Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1.[J].2018.
[10]van Solingen, Coen,Bijkerk, Roel,de Boer, Hetty C.,etc.The Role of microRNA-126 in Vascular Homeostasis[J].2015,13(3).
[11]Stitt, Alan W.,Curtis, Timothy M.,Chen, Mei,etc.The progress in understanding and treatment of diabetic retinopathy[J].2016,51.
[12]Zampetaki, Anna,Willeit, Peter,Burr, Simon,etc.Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes[J].2016,65(1).
[13]Qi Jiang,Xue-Man Lyu,Yi Yuan,etc.Plasma miR-21 expression: an indicator for the severity of Type 2 diabetes with diabetic retinopathy.[J].2017,37(2).
[14]Jin HM,Wang XH,Chen SF,etc.MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats.[J].2009,36(2).
[15]Zeng,J.,Xiong,Y.,Li,G.,etc.MiR-21 is overexpressed in response to high glucose and protects endothelial cells from apoptosis[J].2013,121(7).
[16]Doron, Aronson,Elliot J, Rayfield.How hyperglycemia promotes atherosclerosis: molecular mechanisms.[J].2002,1.
[17]Yan, Liu,Yifan, Song,Liyuan, Tao,etc.Prevalence of diabetic retinopathy among 13473 patients with diabetes mellitus in China: a cross-sectional epidemiological survey in six provinces.[J].2017,7(1).
[18]Ryan J, Farr,Andrzej S, Januszewski,Mugdha V, Joglekar,etc.A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.[J].2015,5.
[19]Gomaa, Amir Ramadan,Elsayed, Eman Tayae,Moftah, Reham Fadl.MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy[J].2017,58(3).
[20]Aurora, Mazzeo,Elena, Beltramo,Tatiana, Lopatina,etc.Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects.[J].2018,176(Spec ).
[21]Boulton M,Cai J.The pathogenesis of diabetic retinopathy: old concepts and new questions.[J].2002,16(3).
[22]Li-Li Qin,Mei-Xia An,Yan-Li Liu,etc.MicroRNA-126:a promising novel biomarker in peripheral blood for diabetic retinopathy[J].2017,(4).
[23]Yin,K.-J.,Olsen,K.,Hamblin,M.,etc.Vascular endothelial cell-specific MicroRNA-15a inhibits angiogenesis in hindlimb ischemia[J].2012,287(32).
[24]Stitt AW,Curtis TM,Gardiner TA.Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?[J].2009,23(7).
[25]Stenina-Adognravi,O..Thrombospondins: Old players, new games[J].2013,24(5).
[26]Joglekar, Mugdha V.,Januszewski, Andrzej S.,Jenkins, Alicia J.,etc.Circulating microRNA Biomarkers of Diabetic Retinopathy[J].2016,65(1).
[27]Solomon, Sharon D.,Chew, Emily,Duh, Elia J.,etc.Diabetic Retinopathy: A Position Statement by the American Diabetes Association[J].2017,40(3).
[28]Qing,Shao,Yuan,Songtao,Yun,Chen.Serum MiRNA Biomarkers serve as a Fingerprint for Proliferative Diabetic Retinopathy.[J].2014,34(5).
[29]Santoro MM,Wythe JD,Srivastava D,etc.miR-126 regulates angiogenic signaling and vascular integrity.[J].2008,15(2).
[30]Zampetaki,A.,Willeit,P.,Tilling,L.,etc.Prospective study on circulating microRNAs and risk of myocardial infarction[J].2012,60(4).
[31]Roberts DD,Kaur S,Pendrak ML,etc.Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.[J].2010,285(50).
[32]The Eye Diseases Prevalence Research Group.The Prevalence of Diabetic Retinopathy Among Adults in the United States.[J].2004,122(4).
[33]Song, S. -J.,Yang, T. -T.,Xue, H. -B.,etc.Regulatory T cells in the pathogenesis of type 2 diabetes mellitus retinopathy by miR-155[J].2015,19(11).
[34]Long J,Danesh FR,Wang W,etc.Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.[J].2010,285(30).
[35]Kutter C,Git A,Hadfield J,etc.Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression.[J].2010,16(5).
[36]Jae Seung, Yun,Tae Seok, Lim,Seon Ah, Cha,etc.Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea.[J].2016,(6).
[37]Saul, Genuth,K G M M, Alberti,Peter, Bennett,etc.Follow-up report on the diagnosis of diabetes mellitus.[J].2003,26(11).
[38]Rodolfo Mastropasqua,Lisa Toto,Francesco Cipollone,etc.Role of microRNAs in the modulation of diabetic retinopathy[J].2014,43.
[39]En-Hui, Li,Qin-Zhu, Huang,Gao-Chun, Li,etc.Effects of miRNA-200b on the development of diabetic retinopathy by targeting VEGFA gene.[J].2017,37(2).
[40]Cheung N,Mitchell P,Wong TY.Diabetic retinopathy.[J].2010,376(9735).
[41]Hammes HP,Feng Y,Pfister F,etc.Diabetic retinopathy: targeting vasoregression.[J].2011,60(1).
[42]Boulton M,Foreman D,Williams G,etc.VEGF localisation in diabetic retinopathy.[J].1998,82(5).
[43]Amador AG,Zinman B,Ciulla TA.Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies.[J].2003,26(9).
[44]Zou, Hui-Ling,Wang, Yan,Gang, Qiang,etc.Plasma level of miR-93 is associated with higher risk to develop type 2 diabetic retinopathy[J].2017,255(6).