Paper - WANFANG MED ONLINE

You Position: Home > Paper

Contactins in the central nervous system: role in health and disease

( views:16, downloads:0 )

Author:: No author available

Journal Title:: Neural Regeneration Research

Issue:: 2

DOI:: 10.4103/1673-5374.244776

Key Word:: cell adhesion molecule;Contactins;axonal domain,neurogenesis;synaptogenesis;autism spectrum disorder;neuro-developmental disorder;neurological disease

Abstract： Contactins are a group of cell adhesion molecules that are mainly expressed in the brain and play pivotal roles in the organization of axonal domains,axonal guidance,neuritogenesis,neuronal development,synapse formation and plasticity,axo-glia interactions and neural regeneration.Contactins comprise a family of six members.Their absence leads to malformed axons and impaired nerve conduction.Contactin mediated protein complex formation is critical for the organization of the axon in early central nervous system development.Mutations and differential expression of contactins have been identified in neuro-developmental or neurological disorders.Taken together,contactins are extensively studied in the context of nervous system development.This review summarizes the physiological roles of all six members of the Contactin family in neurodevelopment as well as their involvement in neurological/neurodevelopmental disorders.

Reference

[1]Yan Zou,Wei-feng Zhang,Hai-ying Liu,etc.Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases[J].2017,(9).
[2]Lin, Jin-Fei,Pan, Hong-Chao,Ma, Li-Ping,etc.The Cell Neural Adhesion Molecule Contactin-2 (TAG-1) Is Beneficial for Functional Recovery after Spinal Cord Injury in Adult Zebrafish.[J].2012,7(12).
[3]Shimazaki K,Toyoshima M,Shimoda Y,etc.Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem.[J].2009,513(4).
[4]Catherine E, Cottrell,Natalie, Bir,Elizabeth, Varga,etc.Contactin 4 as an autism susceptibility locus.[J].2011,4(3).
[5]Hartmann, Andreas,Osiecki, Lisa,Berlin, Cheston,etc.Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome[J].2017,94(6).
[6]Hogl,S.,Roner,S.,Haass,C.,etc.Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons[J].2012,31(14).
[7]Compton AG,Albrecht DE,Seto JT,etc.Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy.[J].2008,83(6).
[8]Watkins, DJ,Bouyain, S.The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules[J].2010,107(6).
[9]Bagshaw R,Wakutani Y,Horne P,etc.The in Vivo brain interactome of the amyloid precursor protein[J].2008,7(1).
[10]D P, Wolfer,A, Henehan-Beatty,E T, Stoeckli,etc.Distribution of TAG-1/axonin-1 in fibre tracts and migratory streams of the developing mouse nervous system.[J].1994,345(1).
[11]Joseph T, Glessner,Kai, Wang,Guiqing, Cai,etc.Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.[J].2009,459.
[12]Schlessinger J.,Schilling J.,Grumet M.,etc.Identification of a Novel Contactin-Associated Transmembrane Receptor with Multiple Domains Implicated in Protein-Protein Interactions[J].1997,16(5).
[13]Peles E,Poliak S.The local differentiation of myelinated axons at nodes of Ranvier.[J].2003,4(12).
[14]Burbach JP,van-der-Zwaag B.Contact in the genetics of autism and schizophrenia.[J].2009,32(2).
[15]Ohyagi Y,Kikuchi H,Shibata A,etc.The contactin 4 gene locus at 3p26 is a candidate gene of SCA16.[J].2006,67(7).
[16]Girault JA,Watanabe K,Goutebroze L,etc.Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.[J].2003,162(6).
[17]Lu Y,Bellen HJ,Beckstead R,etc.Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia.[J].1998,21(10).
[18]Rozenkrantz, Liron,Zachor, Ditza,Heller, Iris,etc.A Mechanistic Link between Olfaction and Autism Spectrum Disorder[J].2015,25(14).
[19]Faivre Sarrailh-C,Gauthier F,Denisenko Nehrbass-N,etc.The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr).[J].2000,149(2).
[20]Vivek, Gautam,Carla, D'Avanzo,Matthias, Hebisch,etc.BACE1 activity regulates cell surface contactin-2 levels.[J].2014,9.
[21]M, Yamamoto,A M, Boyer,J E, Crandall,etc.Distribution of stage-specific neurite-associated proteins in the developing murine nervous system recognized by a monoclonal antibody.[J].1986,6.
[22]C, Faivre-Sarrailh,G, Gennarini,C, Goridis,etc.F3/F11 cell surface molecule expression in the developing mouse cerebellum is polarized at synaptic sites and within granule cells.[J].1992,12.
[23]Savvaki, Maria,Vidaki, Marina,Karagogeos, Domna,etc.Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells[J].2015,142(24).
[24]Hu QD,Ma QH,Gennarini G,etc.Cross-talk between F3/contactin and Notch at axoglial interface: a role in oligodendrocyte development.[J].2006,28(1/2).
[25]Gabby, Rudenko.Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity.[J].2017,2017(Spec ).
[26]J. Dodd,S.B. Morton,D. Karagogeos,etc.Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons[J].1988,1(2).
[27]Mark P. Mattson.TAGing APP constrains neurogenesis[J].2008,10(3).
[28]Masuda, Tomoyuki.Contactin-2/TAG-1, active on the front line for three decades[J].2017,11(5).
[29]Peles E,Salzer JL,Brophy PJ.Molecular Domains of Myelinated Axons in the Peripheral Nervous System[J].2008,56(14).
[30]Fillbrandt R,Muller S,Lamszus K,etc.Contactin is expressed in human astrocytic gliomas and mediates repulsive effects[J].2006,53(1).
[31]Heck N,Faissner A,Dobbertin A,etc.DSD-1-Proteoglycan/Phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues.[J].2006,557(0).
[32]Peles E,Berglund EO,Weber L,etc.Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.[J].2001,30(2).
[33]Watanabe,K.,Shimoda,Y.,Huang,Z.,etc.Loss of neural recognition molecule NB-3 delays the normal projection and terminal branching of developing corticospinal tract axons in the mouse[J].2012,520(6).
[34]Virgintino D,Ambrosini M,D'Errico P,etc.Regional distribution and cell type-specific expression of the mouse F3 axonal glycoprotein: a developmental study.[J].1999,413(3).
[35]Tsutsumi O,Watanabe K,Taketani Y,etc.cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human.[J].1998,51(3).
[36]Konietzko,U..AICD nuclear signaling and its possible contribution to Alzheimer's disease[J].2012,9(2).
[37]Chen QY,Feng GY,Tang J,etc.Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population.[J].2005,73(2).
[38]Watanabe K,Kaneko H,Hosoya H,etc.Novel neural adhesion molecules in the Contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain.[J].1996,218(3).
[39]Kleijer,K.T.E.,Kas,M.J.H.,VanDerZwaag,B.,etc.Contactins in the neurobiology of autism[J].2013,719(1).
[40]Puzzo, Daniela,Bizzoca, Antonella,Loreto, Carla,etc.Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice[J].2015,36(4).
[41]Eric M. Morrow,Seung-Yun Yoo,Steven W. Flavell,etc.Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry[J].2008,321(5886).
[42]Watanabe,K.,Itoh,M.,Koseki,F.,etc.A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane[J].2012,510(2).
[43]A J, Furley,S B, Morton,D, Manalo,etc.The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity.[J].1990,61(1).
[44]Quan-Hong Ma,Dominique Bagnard,Zhi-Cheng Xiao,etc.A TAG on to the neurogenic functions of APP[J].2008,2(1).
[45]A F, Williams,A N, Barclay.The immunoglobulin superfamily--domains for cell surface recognition.[J].1988,6.
[46]Araque,J.,Gallardo,E.,Diaz-Manera,J.,etc.Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy[J].2013,73(3).
[47]T, Koch,T, Brugger,A, Bach,etc.Expression of the immunoglobulin superfamily cell adhesion molecule F3 by oligodendrocyte-lineage cells.[J].1997,19(3).
[48]Lu, Zhuoyang,Reddy, M. V. V. V. Sekhar,Liu, Jianfang,etc.Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2)[J].2016,291(46).
[49]M A, Connelly,R C, Grady,J F, Mushinski,etc.PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas.[J].1994,91.
[50]Colman DR,Pedraza L,Huang JK.Organizing principles of the axoglial apparatus.[J].2001,30(2).
[51]J Christopher, Edgar,Charles L, Fisk Iv,Jeffrey I, Berman,etc.Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex.[J].2015,6.
[52]Misner D,Murai KK,Ranscht B.Contactin supports sybaptic plasticity associated with hippocampal long-term depression but not potentiation[J].2002,12(3).
[53]Thomas Fernandez,Thomas Morgan,Nicole Davis,etc.Disruption of Contactin 4 (CNTN4) Results in Developmental Delay and Other Features of 3p Deletion Syndrome[J].2004,74(6).
[54]Okabe E,Takagishi Y,Sun XY.A novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial interactions of myelinated nerves.[J].2009,68(11).
[55]Taylor MK,Yeager K,Morrison SJ.Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.[J].2007,134(13).
[56]Suni Lee,Yasuo Takeda,Hitoshi Kawano,etc.Expression and regulation of a gene encoding neural recognition molecule NB-3 of the contactin/F3 subgroup in mouse brain[J].2000,245(2).
[57]Yoshihiro Yoshihara,Miwa Kawasaki,Akiko Tani,etc.BIG-1: A new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity[J].1994,13(2).
[58]Mercati, O.,Huguet, G.,Danckaert, A.,etc.CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders[J].2017,22(4).
[59]Kleijer, K. T. E.,Zuko, A.,Shimoda, Y.,etc.Contactin-5 Expression During Development and Wiring of the Thalamocortical System[J].2015,310.
[60]Peterson BS,Tobe RH,Xu D,etc.Cerebellar morphology in Tourette syndrome and obsessive-compulsive disorder.[J].2010,67(4).
[61]Karsak M,Takeda Y,Yu FG,etc.NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.[J].2004,279(24).
[62]Bear MF,Kelleher RJ.The Autistic Neuron: Troubled Translation?[J].2008,135(3).
[63]Carratù, M.R.,Corsi, P.,Massaro, A.,etc.Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development[J].2012,50(3).
[64]Bastian Dislich,Felix Wohlrab,Teresa Bachhuber,etc.Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.[J].2015,14(10).
[65]Berglund EO,Ranscht B,Sekerkova G,etc.Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression.[J].1999,24(3).
[66]Tegay DH,Roohi J,Montagna C.Disruption of contactin 4 in three subjects with autism spectrum disorder.[J].2009,46(3).
[67]Ramaker, Jenna M.,Swanson, Tracy L.,Copenhaver, Philip F..Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration[J].2016,36(33).
[68]Popko B,Dupree JL,Traka M,etc.The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers.[J].2002,22(8).
[69]Baumann N,Pham-Dinh D.Biology of oligodendrocyte and myelin in the mammalian central nervous system.[J].2001,81(2).
[70]Watanabe K,Sakurai K,Shimoda Y,etc.Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3.[J].2010,473(2).
[71]Hashimoto K,Kawano H,Sudo K,etc.Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup.[J].2003,56(3).
[72]Zeng L,Kalousek MB,Pallen CJ,etc.Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn.[J].1999,147(4).
[73]Shimazaki K,Takeda Y,Hosoya H,etc.Age-related decline of F3/contactin in rat hippocampus.[J].1998,245(2).
[74]Karagogeos D,de Diego I,Kyriakopoulou K,etc.A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla.[J].2002,129(2).
[75]Sanes, Joshua R.,Tran, Nicholas M.,Martersteck, Emily M.,etc.Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell[J].2017,95(4).
[76]Kayser MS,Dalva MB,McClelland AC.Cell adhesion molecules: signalling functions at the synapse[J].2007,8(3).
[77]Kumar RA,Christian SL.Genetics of autism spectrum disorders.[J].2009,9(3).
[78]Lamprianou, S.,Chatzopoulou, E.,Thomas, J.-L.,etc.A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells[J].2011,108(42).
[79]Shimoda Y,Takeda Y,Ueda H,etc.Contribution of the neural cell recognition molecule NB-3 to synapse formation between parallel fibers and Purkinje cells in mouse.[J].2009,69(12).
[80]T. Karayannis,E. Au,J. C. Patel,etc.Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission[J].2014,511(Jul.10 TN.7508).
[81]Nava,C.,Keren,B.,Mignot,C.,etc.Prospective diagnostic analysis of copy number variants using SNP microarrays in individuals with autism spectrum disorders[J].2014,22(1).
[82]Ashrafi,S.,Betley,J.,Comer,J.,etc.Neuronal Ig/Caspr Recognition Promotes the Formation of Axoaxonic Synapses in Mouse Spinal Cord[J].2014,81(1).
[83]Sherman DL,Macklin WB,Zonta B,etc.Neurofascins are required to establish axonal domains for saltatory conduction.[J].2005,48(5).
[84]Salzer JL,Peles E.Molecular domains of myelinated axons.[J].2000,10(5).
[85]Rios JC,Grumet M,Melendez-Vasquez CV,etc.Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination.[J].2000,20(22).
[86]Yoshihara S,Miyazaki H,Yoshihara Y,etc.BIG-2 mediates olfactory axon convergence to target glomeruli.[J].2008,57(6).
[87]Urretavizcaya M,Brunet A,Fernandez Aranda F,etc.Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.[J].2010,44(14).
[88]Simmons, D. R.,Robertson, A. E.,McKay, L. S.,etc.Vision in autism spectrum disorders[J].2009,49(22).
[89]Koike, Haruki,Kadoya, Masato,Kaida, Ken-ichi,etc.Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies[J].2017,88(6).
[90]Muriel T, Davisson,Roderick T, Bronson,Abigail L D, Tadenev,etc.A spontaneous mutation in contactin 1 in the mouse.[J].2011,6(12).
[91]Zuellig, Richard A.,Rader, Christoph,Schroeder, Annelies,etc.The axonally secreted cell adhesion molecule, axonin-1.[J].1992,204(2).
[92]Catherine, Faivre-Sarrailh,Jér?me J, Devaux.Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases.[J].2013,7.
[93]Ogawa J,Takeda Y,Itoh K,etc.Neural recognition molecule NB-2 of the contactin/F3 subgroup in rat: Specificity in neurite outgrowth-promoting activity and restricted expression in the brain regions.[J].2001,65(2).
[94]Alma N, Mohebiany,Sheila, Harroch,Samuel, Bouyain.New insights into the roles of the contactin cell adhesion molecules in neural development.[J].2014,8.
[95]Esther T.Stoeckli.Neural circuit formation in the cerebellum is controlled by cell adhesion molecules of the Contactin family[J].2010,4(4).
[96]H, Umemori,S, Sato,T, Yagi,etc.Initial events of myelination involve Fyn tyrosine kinase signalling.[J].1994,367(6463).
[97]Labasque,M.,Hivert,B.,Nogales-Gadea,G.,etc.Specific contactin N-glycans are implicated in neurofascin binding and autoimmune targeting in peripheral neuropathies[J].2014,289(11).
[98]E T, Stoeckli,T B, Kuhn,C O, Duc,etc.The axonally secreted protein axonin-1 is a potent substratum for neurite growth.[J].1991,112.
[99]Puzzo,D.,Bizzoca,A.,Privitera,L.,etc.F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice[J].2013,23(12).
[100]Shimoda Y,Watanabe K.Contactins: emerging key roles in the development and function of the nervous system.[J].2009,3(1).
[101]Ma QH,Takeda Y,Xu RX,etc.A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis[J].2008,10(3).
[102]Watanabe K,Teramoto K,Tsutsumi O,etc.Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.[J].2000,69(1).
[103]Labasque M,Faivre Sarrailh C.GPI-anchored proteins at the node of Ranvier.[J].2010,584(9).
[104]Becker,E.B.E.,Zuliani,L.,Pettingill,R.,etc.Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia[J].2012,83(4).
[105]Watanabe K,Akasaka K,Kai N,etc.Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2.[J].2003,17(5).