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Developing biomarkers for neurodegenerative diseases using genetically-modified common marmoset models
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- Author:
- No author available
- Journal Title:
- Neural Regeneration Research
- Issue:
- 7
- DOI:
- 10.4103/1673-5374.235028
- Key Word:
- No keyword available
Abstract： Mouse and non-human primate models of neurodegenerative disease:The prevalence of age-related neurodegenerative diseases continues to increase with ever increasing aging population over the age of 60.Although the difficulties associated with neurodegenerative diseases present an urgent global issue,there is no effective treatment for these conditions.To develop therapeutic methods and therapeutic agents for neurodegenerative diseases,model animals that simulate the human disease pathology are eagerly anticipated.
- [1]Anthony W. S. Chan.Progress and Prospects for Genetic Modification of Nonhuman Primate Modelsin Biomedical Research[J].2013,54(2).
- [2]A, Yamamoto,J J, Lucas,R, Hen.Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.[J].2000,101(1).
- [3]Crews L,Masliah E,Rockenstein E.Transgenic animal models of neurodegenerative diseases and their application to treatment development.[J].2007,59(11).
- [4]Jin, Yong-Xun,Jeon, Yubyeol,Lee, Sung-Hyun,etc.Production of Pigs Expressing a Transgene under the Control of a Tetracycline-Inducible System.[J].2014,9(1).
- [5]Erika Sasaki,Hiroshi Suemizu,Akiko Shimada,etc.Generation of transgenic non-human primates with germline transmission[J].2009,459(TN.7246).
- [6]Schmidt T,Wolburg,Boy J.Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3.[J].2009,18(22).
- [7]Sato, Kenya,Oiwa, Ryo,Kumita, Wakako,etc.Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing[J].2016,19(1).
- [8]Giuliani, Daniela,Ottani, Alessandra,Neri, Laura,etc.Multiple beneficial effects of melanocortin MC4 receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives[J].2017,148.
- [9]Worley,K.C.,Warren,W.C.,Rogers,J.,etc.The common marmoset genome provides insight into primate biology and evolution[J].2014,46(8).
- [10]Brotchi J,Bender HU,Tenenbaum L,etc.Tetracycline-inducible transgene expression mediated by a single AAV vector.[J].2003,10(1).
- [11]Osamu Takayama,Kensuke Owari,Ikuo Tomioka,etc.Generation of transgenic marmosets using a tetracyclin-inducible transgene expression system as a neurodegenerative disease model[J].2017,97(5).