Vasopressin decreases neuronal apoptosis during cardiopulmonar y resuscitation
- Author:
- No author available
- Journal Title:
- Neural Regeneration Research
- Issue:
- 6
- DOI:
- 10.4103/1673-5374.130107
- Key Word:
- nerve regeneration;brain injury;cardiopulmonary resuscitation;epinephrine;vasopressin;c-Jun N-terminal kinase;p38 mitogen activated protein kinase;cardiac arrest;neural regeneration
Abstract： The American Heart Association and the European Resuscitation Council recently recommend-ed that vasopressin can be used for cardiopulmonary resuscitation, instead of epinephrine. However, the guidelines do not discuss the effects of vasopressin during cerebral resuscitation. In this study, we intraperitoneally injected epinephrine and/or vasopressin during cardiopul-monary resuscitation in a rat model of asphyxial cardiac arrest. The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were signiifcantly decreased in the hippo-campus after treatment with vasopressin alone or the vasopressin and epinephrine combination. No signiifcant difference in resuscitation effects was detected between vasopressin alone and the vasopressin and epinephrine combination. These results suggest that vasopressin alone or the vasopressin and epinephrine combination suppress the activation of mitogen-activated protein kinase and c-Jun N-terminal kinase signaling pathways and reduce neuronal apoptosis during cardiopulmonary resuscitation.
- [1]李广明,李军,曹红,等.p38MAPK在沙土鼠脑缺血再灌注海马神经元损伤中的作用[J].2004,(4).
- [2]Tyler ZARUBIN,Jiahuai Han.Activation and signaling of the p38 MAP kinase pathway[J].2005,(1).
- [3]欧好,杨明施,孙蓓,等.肾上腺素联合血管加压素在窒息家兔心肺复苏中的应用[J].2006,(7).
- [4]孟庆义.心肺复苏时肾上腺素剂量变迁的思考[J].2007,(8).
- [5]Lindner K. H.,Haak T.,Keller A.,etc.Release of endogenous vasopressors during and after cardiopulmonary resuscitation.[J].1996.
- [6]Klassen T,Clement C,Vandemheen KL,etc.Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.[J].2001,358(9276).
- [7]Kim,S.J.,Lee,S.H.,Lee,C.S.,etc.Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3β and inhibition of p38 MAPK and JNK[J].2012,17(4).
- [8]Wenzel,V,Lindner,KH,Prengel,AW,etc.Vasopressin improves vital organ blood flow after prolonged cardiac arrest with postcountershock pulseless electrical activity in pigs (see comments)[J].1999,27(3).
- [9]Igarashi H,Obata Y,Sato S,etc.Vasopressin and epinephrine are equally effective for CPR in a rat asphyxia model.[J].2002,52(2).
- [10]Bamford M,Irving EA.Role of mitogen- and stress-activated kinases in ischemic injury.[J].2002,22(6).
- [11]J, Wortsman,N A, Paradis,G B, Martin,etc.Functional responses to extremely high plasma epinephrine concentrations in cardiac arrest.[J].1993,21.
- [12]Mizushima H,Nakai Y,Matsumoto K,etc.Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway.[J].1999,262(1).
- [13]Prengel AW,Linder KH,Strohmenger HU,etc.Vasopressin combined with epinephrine decreases cerebral perfusion compared with vasopressin alone during cardiopulmonary resuscitation in pigs.[J].1998,29(7).
- [14].Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats[J].2013,288(6).
- [15]K H, Lindner,A W, Prengel,E G, Pfenninger,etc.Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs.[J].1995,91.
- [16]Monika Strniskova,Miroslav Barancik,Tana Ravingerova.Mitogen-activated protein kinases: A new therapeutic target in cardiac pathology[J].2003,247(1).
- [17]I, Hubloue,I, Lauwaert,L, Corne.Adrenaline dosage during cardiopulmonary resuscitation: a critical review.[J].1994,1.
- [18]C, van Walraven,I G, Stiell,G A, Wells,etc.Do advanced cardiac life support drugs increase resuscitation rates from in-hospital cardiac arrest? The OTAC Study Group.[J].1998,32.
- [19]Krismer AC,Mueller T,Lindner KH,etc.Developing a vasopressor combination in a pig model of adult asphyxial cardiac arrest.[J].2001,104(14).
- [20]Kolahgar G,Bardet PL,Langton PF,etc.Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila.[J].2011,138(14).
- [21]Sitter H,Lindner KH,Arntz HR,etc.A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation.[J].2004,350(2).
- [22]Kenneth R. Sirinek,Deborah K. Adcock,Barry A. Levine.Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting[J].1989,157(1).