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Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

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Author:: No author available

Journal Title:: Neural Regeneration Research

Issue:: 6

DOI:: 10.4103/1673-5374.130103

Key Word:: nerve regeneration;peripheral nerve injury;muscle spindle;vein;tibial nerve;gastroc-nemius muscle;neurofilament protein H;neural regeneration

Abstract： Motor reinnervation after repair of tibial nerve defects using autologous vein grafts in rats has previously been reported, but sensory reinnervation after the same repair has not been fully investigated. In this study, partial sensory reinnervation of muscle spindles was observed after repair of 10-mm left tibial nerve defects using autologous vein grafts with end-to-end anasto-mosis in rats, and functional recovery was conifrmed by electrophysiological studies. There were no signiifcant differences in the number, size, or electrophysiological function of reinnervated muscle spindles between the two experimental groups. These ifndings suggest that repair of short nerve defects with autologous vein grafts provides comparable results to immediate end-to-end anastomosis in terms of sensory reinnervation of muscle spindles.

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