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Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

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Author:: No author available

Journal Title:: Neural Regeneration Research

Issue:: 35

DOI:: 10.3969/j.issn.1673-5374.2013.35.005

Key Word:: neural regeneration;traditional Chinese medicine;multiple sclerosis;experimental autoimmune encephalomyelitis;Bushen Yisui Capsule;amyloid precursor protein;microtubule-associated protein 2;grants-supported paper;neuroregeneration

Abstract： A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly cal ed Er-huang Formula) in combination with conventional therapy is an effective prescription for the treat-ment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis re-mains unclear. In this study, a MOG 35-55-immunized C57BL/6 mouse model of experimental au-toimmune encephalomyelitis was intragastrical y administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoim-mune encephalomyelitis was mediated by amelioration of axonal damage and promotion of rege-neration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

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