Abstract： Objective To explore the relationship between the expression level changes,prognostic value and immune cell infiltration of SSX1 in ovarian cancer.Methods The Cancer Genome Atlas(TCGA)and the Genotype-Tissue Expression(GTEx)were served as data resources.Wilcoxon rank test was performed to e-valuate the expression difference of the SSX1 between cancer tissues and normal tissues.Kaplan-Meier plotter and Cox regression were used for prognosis evaluation.The Tumor IMmune Estimation Resource website was used to analyze the relationship between SSX1 and immune cell infiltration in OV.Results The expression level of SSX1 mRNA in ovarian cancer was significantly higher than that in normal ovarian tissue(P＜0.01);Kaplan Meier plot and COX regression model analysis showed that high expression of SSX1 was associated with poor prognosis in OV patients(P=0.0013),and high expression of SSX1 was an independent risk factor for the prognosis of OV patients.The results of immune infiltration showed that the expression of SSX1 was negatively correlated with various immune infiltrating cells.Conclusion SSX1 is highly expressed in OV pa-tients,and its high expression was a independent prognostic factor.The expression of SSX1 was related with the infiltration of immune cells.