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Novel macrolide immunosuppressant, sirolimus F904
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ANTIBIOTICS
- Issue:
- 12
- DOI:
- 10.3969/j.issn.1001-8689.2002.12.002
- Key Word:
- 免疫抑制剂;吸水链霉菌FC904;西罗莫司F904
Abstract： 从福建省福州市的土壤中分离到的链霉菌FC904.经分类鉴定、菌株培养确定为吸水链霉菌.其发酵代谢产物F904具有抗真菌、抗增殖和比环孢素强的免疫抑制活性.分离、纯化、结晶,得F904,经理化性质、光谱分析和X-射线单晶衍射研究证明F904为三烯大环内酯新型强效免疫抑制剂西罗莫司.
- [1]D. C. Neil Swindells,Peter S. White,John A. Findlay.The X-ray crystal structure of rapamycin, C51H79NO13[J].1978,56(18).
- [2]I.Kojima,Y.R.Cheng,V.Mohan,etc.Carbon source nutrition of rapamycin biosynthesis inStreptomyces hygroscopicus[J].1995,14(6).
- [3]NISHIKAWA TAKASHI,SUZUKI SATOMI,OHTANI HIDEKI.Reversible isomerization of rapamycin demonstrated by liquid chromatography.[J].1994.
- [4]戴自英主编 徐肇 等编.临床抗菌药物学[M].1985.
- [5]T, Kino,H, Hatanaka,M, Hashimoto,etc.FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.[J].1987,40.
- [6]C, Vézina,A, Kudelski,S N, Sehgal.Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.[J].1975,28(10).