Paper - WANFANG MED ONLINE

You Position: Home > Paper

细胞焦亡在急性胰腺炎中的分子作用机制研究进展

( views:25, downloads:1 )

Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 6

DOI:: 10.3760/cma.j.cn115667-20210521-00101

Key Word:: 急性胰腺炎;焦亡;炎症小体;Gasdermin D;肠道损伤

Abstract：焦亡是由半胱氨酸天冬氨酸蛋白酶(caspase)介导的作用于Gasdermin蛋白家族的一种程序性细胞死亡，是AP过程中重要的病理学改变。本文就细胞焦亡在AP中的分子作用机制研究进展进行综述。

Reference

[1]A, Zychlinsky,M C, Prevost,P J, Sansonetti.Shigella flexneri induces apoptosis in infected macrophages.[J].1992,358(6382).
[2]Huang, Luqiao,Zhang, Dianliang,Han, Wenli,etc.High-mobility group box-1 inhibition stabilizes intestinal permeability through tight junctions in experimental acute necrotizing pancreatitis[J].2019,68(8).
[3]Dodson, Matthew,de la Vega, Montserrat Rojo,Cholanians, Aram B.,etc.Modulating NRF2 in Disease: Timing Is Everything[J].2019,59.
[4]Kayagaki Nobuhiko,Stowe Irma B.,Lee Bettina L.,etc.Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling[J].2015,526(7575).
[5]Elinav, E.,Strowig, T.,Kau, A.L.,etc.NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis[J].2011,145(5).
[6]Brad T Cookson,Molly A Brennan.Pro-inflammatory programmed cell death[J].2001,9(3).
[7]Kang, Rui,Chen, Ruochan,Xie, Min,etc.The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis[J].2016,196(10).
[8]Yu, Xin,Lan, Peixiang,Hou, Xuben,etc.HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production[J].2017,66(4).
[9]Li, Zhiqiang,Yu, Xiao,Werner, Jens,etc.The role of interleukin-18 in pancreatitis and pancreatic cancer[J].2019,50.
[10]Man, Si Ming,Kanneganti, Thirumala-Devi.Converging roles of caspases in inflammasome activation, cell death and innate immunity[J].2016,16(1).
[11]Peter Szatmary,Wei Huang,David Criddle,etc.Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders[J].2018,22(10).
[12]Garg, Parmod K.,Singh, Vijay P..Organ Failure Due to Systemic Injury in Acute Pancreatitis[J].2019,156(7).
[13]Jiale,Wang,Xia,Li,Yunfei,Liu,etc.CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis.[J].2020,7.
[14]Li Yangxin,Huang Hui,Liu Bin,etc.Inflammasomes as therapeutic targets in human diseases[J].2021,6(1).
[15]Lee, Bettina L.,Stowe, Irma B.,Gupta, Aaron,etc.Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation[J].2018,215(9).
[16]林天娇,潘新亭,万有栋,等.消皮素D通过介导细胞焦亡导致重症急性胰腺炎肠道损伤的机制研究[J].2021,(1).
[17]Algaba-Chueca, Francisco,de-Madaria, Enrique,Lozano-Ruiz, Beatriz,etc.The expression and activation of the AIM2 inflammasome correlates with inflammation and disease severity in patients with acute pancreatitis[J].2017,17(3).
[18]Lingling Jia,Hao Chen,Jun Yang,etc.Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway[J].2020,26(1).
[19]Leema, George,Tamizhselvi, Ramasamy.Protective Effect of Scopoletin Against Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice[J].2018,47(5).
[20]Pan, Xiaohua,Fang, Xin,Wang, Fei,etc.Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms[J].2019,176(23).
[21]Jorgensen, Ine,Rayamajhi, Manira,Miao, Edward A..Programmed cell death as a defence against infection[J].2017,17(3).
[22]Flavell R,Gorelick F,Sarwar S,etc.TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis.[J].2011,141(1).
[23].Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling[J].2016,32.
[24]Orning, Pontus,Weng, Dan,Starheim, Kristian,etc.Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death[J].2018,362(Nov.30 TN.6418).
[25]Jianjin Shi,Wenqing Gao,Feng Shao.Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death[J].2016,42(4).
[26]Xiaojing Xia,Xin Wang,Yi Zheng,etc.What role does pyroptosis play in microbial infection?[J].2019,234(6).
[27].Cordycepin protects against acute pancreatitis by modulating NF-kappa B and NLRP3 inflammasome activation via AMPK[J].2020,251.
[28]Xia, Chen,Hong-Xian, Zhao,Chao, Bai,etc.Blockade of high-mobility group box 1 attenuates intestinal mucosal barrier dysfunction in experimental acute pancreatitis.[J].2017,7(1).
[29]Cen Meng-Er,Wang Feng,Su Ying,etc.Gastrointestinal microecology: a crucial and potential target in acute pancreatitis[J].2018,23(7-8).
[30]Wang, Jianhua,Wang, Lichun,Zhang, Xiaofei,etc.Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis[J].2021,94.
[31]Shi Jianjin,Zhao Yue,Wang Kun,etc.Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death[J].2015,526(7575).
[32]Xue-Yang Li,Cong He,Yin Zhu,etc.Role of gut microbiota on intestinal barrier function in acute pancreatitis[J].2020,(18).
[33]Runkuan Yang,Jyrki Tenhunen,Tor Inge Tonnessen.HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis[J].2017,2017.
[34].TLR4-mediated NF-kappa B signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis[J].2016,37(1).
[35].Mechanisms and Functions of Inflammasomes[J].2014,157(5).
[36]Bauernfeind FG,Horvath G,Stutz A.Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.[J].2009,183(2).
[37]Zhu, Yin,He, Cong,Li, Xueyang,etc.Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice[J].2019,54(4).
[38]Xu, Shan,Wei, Shuqing,Guo, Yu,etc.Involvement of Nucleotide-Binding and Oligomerization Domain-Like Receptors in the Intestinal Injury of Severe Acute Pancreatitis in Rats[J].2018,47(2).
[39]Adam, Janiak,Bartosz, Le?niowski,Anna, Jasińska,etc.Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.[J].2015,10.
[40]Kleszczynski, Konrad,Zillikens, Detlef,Fischer, Tobias W..Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (-GCS, HO-1, NQO1) in ultraviolet radi[J].2016,61(2).