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TRIP6在胰腺癌侵袭及迁移机制中的作用

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-1935.2019.02.020

Key Word:: TRIP6;胰腺癌;信号通路;诊断;治疗

Abstract：胰腺癌起病隐匿,早期诊断率低,进展迅速,治疗效果差,病死率高,因此迫切需要寻找针对胰腺癌有效且新型的诊断、治疗和判断预后的手段.甲状腺激素受体相互作用蛋白6(TRIP6)是一种调节蛋白和局部黏附分子,参与肌动蛋白细胞骨架重组,细胞黏附、迁移和侵袭,抗细胞凋亡和转录调控等.相关研究显示TRIP6表达异常可能在胰腺癌的发生、发展过程中发挥作用.

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