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消退素D1对急性胰腺炎小鼠NLRP3炎症小体通路的影响
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1935.2018.06.012
- Key Word:
- No keyword available
Abstract： 急性胰腺炎( AP)是临床常见急腹症,病情及预后与炎症程度直接相关. AP炎症程度与机体大量炎性递质合成释放有关,抑制炎性递质的合成可减轻AP炎症损伤. 消退素D1作为ω-3多不饱和脂肪酸衍生的内源性抗炎脂质分子,可抑制炎性反应递质合成,减轻AP小鼠胰腺和肺的炎症反应[1-2] ,其机制可能通过抑制NLRP3炎症小体激活减少炎性递质合成[3]. NLRP3炎症小体是机体炎症时调节促炎因子合成的多蛋白复合体[4-5] ,激活的NLRP3 炎症小体可引起IL-1β、HMGB1等促炎因子合成,参与AP炎症损伤[6]. 本研究采用雨蛙肽制备小鼠AP模型,观察消退素D1对AP小鼠胰腺组织NLRP3炎症小体通路的影响,探讨消退素D1的抗炎作用机制.
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