Paper - WANFANG MED ONLINE

You Position: Home > Paper

胰腺癌化疗耐药与肿瘤微环境关系的研究进展

( views:155, downloads:160 )

Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-1935.2018.05.018

Key Word:: No keyword available

Abstract：化疗耐药是大多数癌症患者面临的最大挑战,了解肿瘤细胞耐药的分子机制,对研究新的化疗策略至关重要.相关研究发现,化疗耐药可由肿瘤细胞的内在微环境来介导.肿瘤微环境一般是指实体瘤所处的局部生物环境,包括癌变细胞和周围良性基质细胞,后者通常由炎症细胞、平滑肌细胞、脂肪细胞、成纤维细胞、神经内分泌细胞、内皮细胞及微血管等组成,此外还有细胞因子、生长因子、低pH、低氧和各种细胞外基质等[1].对于实体肿瘤,尤其是胰腺癌,肿瘤微环境在耐药性的形成中发挥重要作用[2].因此明确肿瘤微环境在胰腺癌化疗耐药中的作用机制,并寻找逆转胰腺癌细胞耐药的方法具有重要意义.本文就胰腺癌的化疗耐药与肿瘤微环境之间的关系做一综述.

Reference

[1]Claire, Tonry,John, Armstrong,Stephen, Pennington.Probing the prostate tumour microenvironment II: Impact of hypoxia on a cell model of prostate cancer progression.[J].2017,8(9).
[2].Gemcitabine resistance in pancreatic ductal adenocarcinoma[J].2015,23.
[3]Singh, Yuvraj,Pawar, Vivek Kumar,Meher, Jaya Gopal,etc.Targeting tumor associated macrophages (TAMs) via nanocarriers[J].2017,254.
[4]Xin-Gang, Cui,Zhi-Tao, Han,Shao-Hui, He,etc.HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells.[J].2017,8(15).
[5]陈斐,齐心一,戴悦,等.肿瘤微环境与肿瘤耐药的研究进展[J].2014,(10).
[6]Papageorgis, Panagiotis,Stylianopoulos, Triantafyllos.Role of TGF beta in regulation of the tumor microenvironment and drug delivery[J].2015,46(3).
[7]Michael Friberg Bruun Nielsen,Michael Bau Mortensen,S?nke Detlefsen.Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells[J].2016,(9).
[8]Sousa, Cristovao M.,Biancur, Douglas E.,Wang, Xiaoxu,etc.Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion[J].2016,536(Aug.25 TN.7617).
[9]Brown, J. Martin,Recht, Lawrence,Strober, Samuel.The Promise of Targeting Macrophages in Cancer Therapy[J].2017,23(13).
[10]S, Shi,J, Xu,B, Zhang,etc.VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1α Up-Regulation.[J].2016.
[11].Targeting tumor-associated macrophages to combat pancreatic cancer.[J].2016,(31).
[12].Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer[J].2016,48(12).
[13]Levin, G. Ya.,Sukhareva, E. G..Antithrombin Activity of Erythrocyte Microvesicles[J].2017,162(6).
[14]Satoshi, Koyama,Shinji, Matsunaga,Masaki, Imanishi,etc.Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model.[J].2017,7(Spec ).
[15]Weizman,N.,Krelin,Y.,Shabtay-Orbach,A.,etc.Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase[J].2014,33(29).
[16]Chunhua, Chen,Xiangling, Wang,Juemin, Fang,etc.EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression.[J].2017,8(26).
[17]Habtezion, Aida,Edderkaoui, Mouad,Pandol, Stephen J..Macrophages and pancreatic ductal adenocarcinoma[J].2016,381(1).
[18]Li Huang,Bin Hu,Jianbo Ni,etc.Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis[J].2016,(1).
[19]Minciacchi, Valentina R.,Freeman, Michael R.,Di Vizio, Dolores.Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes[J].2015,40.
[20]Zhou, Chenfei,Zhu, Liangjun,Ji, Jun,etc.EGFR High Expression, but not KRAS Status, Predicts Sensitivity of Pancreatic Cancer Cells to Nimotuzumab Treatment In Vivo[J].2017,17(1).
[21]Roberta Melchionna,Pierluigi Iapicca,Francesca Di Modugno,etc.The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome[J].2016,(12).
[22]Tagawa, Atsuko,Yasuda, Mako,Kume, Shinji,etc.Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy[J].2016,65(3).
[23]Hu, Hai,Hang, Jun-Jie,Han, Ting,etc.The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer[J].2016,37(7).
[24]Na, Li,Yang, Li,Zengxun, Li,etc.Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma.[J].2016.
[25]Dauer, Patricia,Nomura, Alice,Saluja, Ashok,etc.Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters[J].2017,17(1).
[26]Pirola, Romano C.,Wilson, Jeremy S.,Apte, Minote.Pancreatic stellate cell: physiologic role, role in fibrosis and cancer[J].2015,31(5).
[27]Pasto, Anna,Porta, Chiara,Amadori, Alberto,etc.Tumor-associated myeloid cells as guiding forces of cancer cell stemness[J].2017,66(8).
[28]Hridayesh, Prakash,Vinod, Nadella,Sandhya, Singh,etc.CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma.[J].2016.