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慢性胰腺炎病理学分类研究
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1935.2018.03.021
- Key Word:
- No keyword available
Abstract： 慢性胰腺炎(CP)是一类由不同原因(胆道梗阻、酒精、遗传、自身免疫性因素等)引起的胰腺弥漫性或局限性炎症性疾病,以胰腺正常组织纤维化、炎症性改变或者胰管阻塞导致胰腺内外分泌功能不可逆性损害为特点,最终导致营养不良和(或)糖尿病[1].CP的基本病理改变[2]表现为不同程度的腺泡细胞损伤、炎症细胞浸润和弥漫性、节段性或局限性纤维化或钙化,胰管有多发性狭窄或囊性扩张,管内可有多发结石或钙化,胰管阻塞区可见局限性水肿、炎症和坏死,也可合并假性囊肿形成.后期胰腺质地变硬,体积缩小,表面苍白呈不规则结节状,外分泌实质组织改建或缺失,胰管系统阻塞,从而不同程度地影响胰腺外分泌甚至内分泌功能.根据相关病理特征,CP可分为慢性钙化性胰腺炎、慢性阻塞性胰腺炎、慢性炎症性胰腺炎、特殊性慢性胰腺炎4类.
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