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胰腺高级别上皮内瘤变及其miRNA的研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1935.2013.06.024
- Key Word:
- No keyword available
Abstract： 胰腺上皮内瘤变(pancreatic intraepithelial neoplasia,PanIN)是指胰腺中小导管上皮细胞从不典型增生至原位癌这一系列病变的连续过程,根据其组织学异型性可分为3期,其中PanIN-1、2期为低级别,PanIN-3期为高级别[1-3].目前已经证实PanIN-3期是胰腺癌最直接的癌前病变[4].如果能在该期作出诊断,及时进行干预和治疗,是完全可以治愈胰腺癌的.因此寻找此期的特异性标志物是解决问题的关键.近年研究表明,miRNA不仅在肿瘤组织和细胞中的表达具有显著的肿瘤相关性、组织特异性和表达稳定性[5],而且在外周血中的表达同样具有肿瘤相关性和组织特异性,与RNA比较,其表达稳定性更为显著,因此认为外周血miRNA可能是一种理想的肿瘤分子标志物.同样,胰液中miRNAs检测也是早期诊断胰腺疾病的重要途径[6].因此,筛查和鉴定PanIN-3期组织和血或胰液中特异表达的miRNAs,探讨其作为胰腺癌早期诊断分子标志物的潜在可能性,对于提高胰腺癌的早期诊断率,改善其预后具有非常重要的意义.
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