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脂氧素A4对急性坏死性胰腺炎大鼠肝损伤的保护作用
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1935.2011.06.020
- Key Word:
- No keyword available
Abstract： 脂氧素( lipoxins,LX)即脂加氧酶相互作用的产物(lipoxygenases interaction product),是二十烷家族中花生四烯酸一类的代谢产物.其中LXA4是花生四烯酸脂加氧酶代谢产物,系体内重要的内源性促炎症消退介质.近年来研究发现LXA4及其稳定类似物对多种炎症细胞和炎症相关基因有显著的负性调节作用,是炎症反应的重要"刹车信号"或"停止信号"[1-2].本研究探讨LXA4类似物(lipoxin A4 methyl ester,LXA4-ME)对急性坏死性胰腺炎(ANP)大鼠肝损伤的保护作用,为临床重症急性胰腺炎(SAP)的治疗探索新的策略.
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