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前脑啡肽原及其甲基化与胰腺癌研究进展
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1935.2007.06.027
- Key Word:
- No keyword available
Abstract： @@ 自1975年Hughes等从脑中分离并鉴定出两个脑啡肽即甲啡肽和亮啡肽以后,陆续发现10多种来自不同基因的内源性阿片肽.前脑啡肽原(preproenkephalin, ppENK)作为重要的内源性阿片肽前体,其基因甲基化及降解产物甲硫氨酸-脑啡肽与胰腺癌的发生、发展及治疗关系密切,现综述如下.
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