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Comparison of vascular endothelial growth factor and microvessel density between pancreatic carcinoma and ampullary carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1935.2007.03.012
- Key Word:
- 胰腺肿瘤;壶腹部肿瘤;血管内皮生长因子A;微血管密度
Abstract： 目的 分析血管内皮生长因子(vascular endothelial growth factor, VEGF)和微血管密度(microvessel density, MVD)在胰腺癌和壶腹癌中的表达,探讨血管生成两种肿瘤发展过程中的差别及意义.方法 选取43例胰腺癌和45例壶腹部癌标本,应用免疫组化方法检测VEGF表达和MVD计数.结果 胰腺癌和壶腹部癌在患者性别、年龄、血液肿瘤标志物和肿瘤分化程度等方法无明显差别,但在首发症状、手术方式、术后并发症、肿块大小、病理类型、有无淋巴结转移、TNM分期、治疗结果及生存期等方面吸显著性差异(P＜0.05).胰腺癌VEGF表达阳性率为76.7%,壶腹部癌为73.3%,两者之间无显著性差异(P＞0.05).结论胰腺癌的恶性程度远高于壶腹部癌,胰腺癌的高血管生成活性可能是其原因之一.
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