You Position: Home > Paper
Expression of angiotensin Ⅱ type 1 receptor protein in human pancreatic cancer cell lines
( views:159, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-1935.2003.01.016
- Key Word:
- 血管紧张素Ⅱ;胰腺肿瘤;血管紧张素Ⅱ 1型受体
Abstract： 目的探讨血管紧张素Ⅱ 1型受体(angiotensin Ⅱ type 1 receptor,AT1)在胰腺癌细胞中的表达.方法用免疫细胞化学染色检测胰腺癌细胞系SW1990、PaTu 8988s和PANC-1中AT1蛋白的表达.结果胰腺癌细胞系SW1990、PaTu 8988s和PANC-1中均有AT1蛋白的表达.结论 AT1在胰腺癌细胞生长中可能发挥重要作用,应用AT1拮抗剂对防治胰腺癌似乎有一定意义.
- [1]H, Takeda,S, Kondo.Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression.[J].2001,158(5).
- [2]B, De Paepe,V L, Verstraeten,C R, De Potter,etc.Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma.[J].2001,116(3).
- [3]Ullian M E,Linas S L.Role of receptor cycling in the regulation of angiotensin II surface receptor number and angiotensin II uptake in rat vascular smooth muscle cells.[J].1989.
- [4]William F. Regine,William J. John,Mohammed Mohiuddin.Current and Emerging Treatments for Pancreatic Cancer[J].1997,11(4).
- [5]A T, Chiu,W F, Herblin,D E, McCall,etc.Identification of angiotensin II receptor subtypes.[J].1989,165(1).
- [6]J.L. Duff,B.C. Berk,M.A. Corson.Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells[J].1992,188(1).
- [7]Y, Nishizuka.The molecular heterogeneity of protein kinase C and its implications for cellular regulation.[J].1988,334(6184).