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Characteristics of TNFα and its effects on organ function In infected stage of patients with severe acute pancreatitis

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PANCREATOLOGY
Issue:
1
DOI:
10.3760/cma.j.issn.1674-1935.2001.01.015
Key Word:
重症急性胰腺炎;感染;TNFα;器官功能

Abstract´╝Ü 目的探讨重症急性胰腺炎(SAP)患者感染期TNFa的变化特点,并观察其与器官功能变化的关系.方法测定21例SAP感染期患者的血、尿、胆汁以及正常人血清和胆汁内TNFa活性及肝、肾、肺功能.分为细菌或真菌阳性组(Ⅰ组)和阴性组(Ⅱ组)及正常血清对照组(Ⅲ组)和正常胆汁对照组(Ⅳ组).结果胆汁、尿中有细菌或真菌感染的SAP患者(Ⅰ组),其血清TNFa活性较Ⅱ组显著增高(P<0.01),但痰液细菌或真菌培养阳性的SAP患者,其血清TNFα较Ⅱ组变化不显著;Ⅰ组胆道感染病人的胆汁内TNFα活性较Ⅱ组显著升高(P<0.01);Ⅰ组和Ⅱ组的血清、胆汁TNFα活性均显著高于Ⅲ、Ⅳ组(P<0.01);Ⅰ组的肝、肾、肺功能水平较Ⅱ组显著降低(P<0.05).结论全身感染期血清、胆汁TNFα活性存在高、低两个水平,前者可能与器官功能不全有关,后者维持机体的炎症反应.

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