You Position: Home > Paper
Characteristics of TNFα and its effects on organ function In infected stage of patients with severe acute pancreatitis
( views:140, downloads:16 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-1935.2001.01.015
- Key Word:
- 重症急性胰腺炎;感染;TNFα;器官功能
Abstract： 目的探讨重症急性胰腺炎(SAP)患者感染期TNFa的变化特点,并观察其与器官功能变化的关系.方法测定21例SAP感染期患者的血、尿、胆汁以及正常人血清和胆汁内TNFa活性及肝、肾、肺功能.分为细菌或真菌阳性组(Ⅰ组)和阴性组(Ⅱ组)及正常血清对照组(Ⅲ组)和正常胆汁对照组(Ⅳ组).结果胆汁、尿中有细菌或真菌感染的SAP患者(Ⅰ组),其血清TNFa活性较Ⅱ组显著增高(P＜0.01),但痰液细菌或真菌培养阳性的SAP患者,其血清TNFα较Ⅱ组变化不显著;Ⅰ组胆道感染病人的胆汁内TNFα活性较Ⅱ组显著升高(P＜0.01);Ⅰ组和Ⅱ组的血清、胆汁TNFα活性均显著高于Ⅲ、Ⅳ组(P＜0.01);Ⅰ组的肝、肾、肺功能水平较Ⅱ组显著降低(P＜0.05).结论全身感染期血清、胆汁TNFα活性存在高、低两个水平,前者可能与器官功能不全有关,后者维持机体的炎症反应.
- [1]H P, Grewal,M, Kotb,A M, el Din,etc.Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage.[J].1994,115(2).
- [2]M G, Davies,P O, Hagen.Systemic inflammatory response syndrome.[J].1997,84(7).
- [3].American College of Chest Physicians/ Society of Critical Care Medicine Consensus ConferenceDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis[J].1992,20(6).
- [4]Mariano F,Guida G,Donati D,etc.Production of platelet-activating factor in patients with sepsis-associated acute renal failure.[J].1999,14(5).
- [5]张圣道,张臣烈,汤耀卿,等.急性坏死性胰腺炎全病程演变及治疗对策[J].1997,(3).
- [6]Yang,J,Denham,W,Carter,G,etc.Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor alpha and interleukin-1beta.[J].1998,28(5).
- [7]中华医学会外科学会胰腺学组.急性胰腺炎的临床诊断及分级标准（1996年第二次方案）[J].1997,(12).