Abstract： Objective To explore the curative effect of longmu zhuanggu granules combined with alfacalcidol in the treatment of rickets in children,and to analyze its effects on bone metabolism,growth and development.Methods 70 children with rickets in Jinshui District General Hospital of Zhengzhou City from January 2020 to January 2023 were selected as research objects,and were divided into single group and combined group according to the random odd-even number allocation principle,with 35 cases in each group.The single group was treated with alfacalcidol,and the combined group was treated with longmu zhuanggu granules combined with alfacalcidol.The clinical efficacy,growth and development status,bone metabolism[SOST],type Ⅰ procollagen amino terminal propeptide(PINP),osteocalcin(BGP),type Ⅰ collagen cross-linked carboxy-terminal peptide(CTX-Ⅰ)],serum biochemical indexes[bone alkaline phosphatase(BALP),25-hydroxyvitamin D3[25(OH)D3]and blood phosphorus,blood calcium],vitamin D metabolism related indicators[parathyroid hormone(PTH),vitamin D binding protein(VDBP)]levels of the two groups were compared before and after treatment.Results The total effective rate of combined group was higher than that of single group,and the growth and development status was better than that of single group(P<0.05).After treatment,the serum levels of SOST,PINP,BGP and CTX-Ⅰ in combination group were higher than those in single group(P<0.05);the serum levels of BALP,25(OH)D3,blood phosphorus and blood calcium in combination group were higher than those in single group(P<0.05);the serum PTH level of the combined group was lower than that of the single group,and the VDBP level was higher than that of the single group(P<0.05).Conclusion Longmu zhuanggu granules combined with alfacalcidol can improve bone metabolism,promote the growth and development of children with rickets,and correct the disorder of calcium and phosphorus metabolism and vitamin D metabolism.