Abstract： Objective To investigate the effects of xiangsha liujunzi decoction on the levels of motilin and gastrin in patients with functional dyspepsia(FD)of spleen and stomach qi deficiency.Methods 104 FD patients admitted to Yingtan Hospital of Traditional Chinese Medicine from October 2020 to October 2022 were randomly divided into two groups with 52 cases each.The control group was treated with mosapride tablets plus pancreatic enzyme enteric-coated capsules,and observation group was added with xiangsha liujunzi decoction.The two groups'clinical efficacy,motilin(MOT)level,gastrin(GAS)level,quality of life[Nepin dyspepsia index quality of life(NDLQI)],disease severity[Leeds dyspepsia questionnaire(LDQ)]and adverse reactions were compared.Results After treatment,observation group's total effective rate and MOT level were higher than control group's,and the GAS level,TCM syndrome score,NDLQI and LDQ scores were lower than control group's(P＜0.05).No obvious adverse reactions were observed in the two groups.Observation group's recurrence rate after 6 months of follow-up was lower than control group's(P＜0.05).Conclusion The application of xiangsha liujunzi decoction in FD patients with spleen and stomach qi deficiency is safe and effective,which can improve gastrointestinal hormone levels and clinical symptoms,reduce recurrence rate,improve quality of life,and has good safety.