Abstract： Objective To explore the effect of xuebijing combined with hydrocortisone on the levels of inflammatory factors in patients with sepsis.Methods 90 patients with sepsis admitted to The Second Affiliated Hospital of Guangdong Medical University from January 2022 to April 2023 were selected as the study subjects.They were randomly divided into two groups using a random number method,with 45 patients in the treatment group and 45 patients in the control group.The control group was treated with hydrocortisone,while the treatment group was treated with xuebijing on this basis.After 7 days of treatment,the levels of inflammatory factors,vascular endothelial function,and prognosis of the two groups were compared.Results After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT)and high-sensitivity C-reactive protein(hs CRP)in the two groups were significantly reduced,and the levels of PCT,IL-6 and hs CRP in the treatment group were lower,with statistical difference(P＜0.05);the levels of soluble thrombomodulin(sTM),Von Willebrand factor(vWF)and endothelial specific molecule(ESM-1)in the two groups were significantly lower,and the levels of sTM,vWF and ESM-1 in the treatment group were lower,with statistical difference(P＜0.05);the APACHE Ⅱ and SOFA scores of the two groups significantly decreased,and the APACHE Ⅱ and SOFA scores of the treatment group were lower,with a statistical difference(P＜0.05).Conclusion Xuebijing combined with hydrocortisone can regulate the levels of inflammatory factors,alleviate vascular endothelial damage,and improve prognosis in patients with sepsis.