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Research advances of cell therapy for liver fibrosis with biliary atresia

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Author:
No author available
Journal Title:
Chinese Journal of Pediatric Surgery
Issue:
2
DOI:
10.3760/cma.j.cn421158-20221129-00722
Key Word:
胆道闭锁;肝纤维化;细胞疗法;Biliary atresia;Liver fibrosis;Cell therapy

Abstract: As a common cause of infantile cholestasis, biliary atresia(BA) is characterized by progressive liver fibrosis.As a palliative treatment, Kasai procedure can not completely prevent the progression of liver fibrosis.And over one half of BA patients eventually develop into end-stage cirrhosis and require liver transplantation.Cell therapy is using functional cells for repairing or replacing damaged cells in a specific disease to restore the function of tissue as much as possible.It is one of alternative therapies for liver fibrosis.This review summarized the latest advances of cell-based therapy for BA fibrosis, including endogenous cell repair, exogenous cell repair and immune cell therapy.

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