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Research advances in the roles of noncoding RNAs in pathogenesis and prevention of necrotizing enterocolitis

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Author:: No author available

Journal Title:: Chinese Journal of Pediatric Surgery

Issue:: 8

DOI:: 10.3760/cma.j.cn421158-20210415-00190

Key Word:: 小肠结肠炎，坏死性;早产儿;非编码RNA;外泌体;Enterocolitis, Necrotizing;Preterm infant, Non-coding RNA;Exosome

Abstract： As a severe neonatal intestinal disease, necrotizing enterocolitis (NEC) affects preterm infants predominantly. NEC-related mortality has remained high and its pathogenesis is elusive. Recent studies have demonstrated that noncoding RNAs (ncRNA), especially micro RNAs (miRNA) and long noncoding RNAs (lncRNA), play important roles in the occurrence and progression of inflammatory intestinal diseases. Furthermore, as a new potential prevention for NEC, exosomes contain a huge quantity of effective ingredients, i.e. ncRNAs. This review summarized the roles of ncRNAs in pathogenesis and prevention of NEC so as to provide rationales for developing new control measures.

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