Abstract： Objective:To explore the efficacy of laparoscopic end-to-end ureteroureterostomy (UU) for midureteral obstruction in children and to summarize our institutional management experiences.Methods:From December 2015 to December 2019, clinical data were retrospectively reviewed for 8 children of midureteral obstruction undergoing laparoscopy. There were 6 boys and 2 girls with a mean age of 7.3(3-15) years. The involved side was left (n=3) and right (n=5). There were asymptomatic hydronephrosis (n=2), intermittent abdominal pain (n=5) and recurrent urinary tract infection (n=1). Successful operation was defined as a relief of symptomatic obstruction or an improvement of hydronephrosis. All of them underwent transperitoneal laparoscopic end-to-end UU. Ureter was sutured intermittently with a 6-0 absorbable thread and anastomosis was inclined for non-tension.Results:All of them underwent laparoscopy successfully without any conversion into laparotomy. The mean operative duration was 125.8(110-150) min and the mean length of stay 10.2(9-12) days. No blood transfusion was offered. The causes of obstruction were confirmed intraoperatively as ureteral stenosis (n=3), posterior vena cava ureter (n=4) and ureteral polyp (n=1). During a postoperative follow-up period of over 1 year, clinical symptoms disappeared, hydronephrosis improved markedly and no polyp recurred. All recovered well and were discharged.Conclusion:Congenital midureteral obstruction is rare in clinical practices. Laparoscopic end-to-end UU is safe, effective and mini-invasive for midureteral obstruction in children. Clinical applications are promising.