Abstract: Objective:To evaluate the clinical outcomes of proximal hypospadias using one-stage transverse preputial island tube urethroplasty, summarize and analyze the related factors of complications of primary repair of proximal hypospadias in children.Methods:From December 2012 to January 2022, clinical data were retrospectively reviewed for complications after hypospadias operation in 290 children. Various clinical characteristics were summarized. Age, lesion grade, surgical approaches, diameter of glans, length of neourethra, secondary coverage and preoperative testosterone were examined while potential factors for postoperative complications analyzed by Logistic regression. P<0.05 was deemed as a statistical criterion. Results:Postoperative complications occurred (n=102, 35.17%), including fistulas (n=55, 18.96%), urethral strictures (n=33, 11.38%) and urethral diverticulum (n=14, 4.83%). Statistical analysis indicated that ventral curvature after degloving and transecting urethral plate, length of neourethra and tunica vaginalis flap over neourethra were correlated with postoperative complications ( P<0.05) . Conclusion:Even performed by highly experienced surgeons, proximal hypospadias has remained challenging. Transverse preputial island tube urethroplasty has a high incidence of complications. Urethrocutaneous fistula is one of the most common complications after one-stage operation. Ventral curvature after degloving and transecting urethral plate and tunica vaginalis flap over neourethra are related factors affecting the postoperative complications after proximal hypospadias repair in children.