Abstract： Objective To explore the feasibility and safety of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for hepatoblastoma.Methods In March 2017,ALPPS was performed for 1 case of incapable hepatectomy of PRETEXT IV hepatoblastoma.The clinical data of perioperative period were recorded and analyzed.The first stage operation was to mobilize ligament and ligate left and middle Glissonian branch and then split liver between SⅤ,SⅥ and left liver,SⅦ,SⅧ.The second stage operation was performed 9 days later.And left liver,SⅦ and SⅧ were removed.At Day 16,laparotomy and hepatic duct jejunum Roux-Y anastomosis was performed because of obstructive jaundice.Results The remnant liver volume was 149.6 ml before the first step of operation and it increased by 82％ and 163.8％ to 272.2 ml and 394.7 ml at Days 3 and 7 respectively.The future liver remnant accounted for 32.2 and 85.2％ of liver total volume before the first and second operations.The operative durations for the first and the second operations were 300 and 180 min respectively.After first operation,temperature fluctuated from 38.3 to 38.7 ℃ and became normal at Day 3 postoperatively.The drainage fluid of abdominal cavity was non-biliary exudate.The peak value of ALT/AST (alanine transaminase/aspartate transaminase) reached 488 and 399 U/L at Day 2 postoperatively and then recovered gradually.And after the second operation,liver function recovered well,but obstructive jaundice gradually increased and the maximal value of TB/DB was 88.4/66.4 umol/L.The operative duration of the third operation was 180 min.Jaundice gradually subsided and liver function normalized after operation.At Week 2 after the last operation,liver function and blood coagulation function returned to normal and chemotherapy was continued.Conclusions Despite some complications,ALPPS provides a new treatment option for hepatoblastoma patients with residual liver insufficiency.