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尿道下裂环境和基因因素研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Pediatric Surgery

Issue:: 5

DOI:: 10.3760/cma.j.issn.0253-3006.2013.05.018

Key Word:: No keyword available

Abstract：尿道下裂是男性小儿最为常见的泌尿生殖器畸形之一,是因前尿道发育不全,导致尿道口达不到正常位置的阴茎畸形.尿道下裂可通过手术矫治,但仍可给患儿及其家庭带来经济及精神压力,甚至造成患儿心理障碍、人格扭曲等.发病率因人种而异,近年来呈上升趋势,目前北美地区尿道下裂发病率约为1/250[1],欧洲地区发病率约在0.3％～0.7％[2].研究表明环境和基因因素与尿道下裂密切相关.本文对近年来与尿道下裂相关的环境及基因研究进展作一综述.

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