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肥大细胞与血管瘤

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF PEDIATRIC SURGERY

Issue:: 5

DOI:: 10.3760/cma.j.issn.0253-3006.2006.05.013

Key Word:: No keyword available

Abstract： @@ 一、血管瘤的生物学特点血管瘤是婴幼儿时期最常见的良性肿瘤。其临床特点是在出生后早期迅速的增生,长大至1岁左右,出现缓慢地自行消退.Mulliken根据血管瘤组织学特点将血管瘤分为增生期(proliferating)、消退期(involuting)和消退完成期(involuted)[1].增生期的特点是:毛细血管内皮细胞迅速分裂增生,基膜增厚分层,肥大细胞、巨噬细胞、周细胞等聚集.在消退期,内皮细胞的更新减慢,细胞实质逐渐被纤维脂肪组织所代替.在消退完成期,纤维组织进一步在血管瘤内沉积.多种细胞标志物在血管瘤各期中表达水平不同,对这些细胞标志物进行检测有助于确定血管瘤的分期及为临床治疗提供科学依据[2].

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